Wetting and electro-kinetic properties of solid supported lipid layers
Investigate the electrokinetic properties and wettability of mixed lipid layers in the presence of enzymes and antioxidants and to study the effect of lipids as bio-surfactants on stability of dispersions.
Originality and innovative aspects: Lipids are the principal components of biological membranes which play an essential role in cell life. The fabrication of model membranes opens doors for their practical applications in the design of specific biosensors, targeted drug delivery systems, surface functionalization, chromatographic analysis, gel permeation and others. In spite of the scientific and practical importance, wetting properties of lipid layers with or without the enzymatic action have not been sufficiently investigated. The behavior of lipids as bio-surfactants needs further investigations. Addressing the wettability of the lipid layers, tailoring the wetting properties, and investigation of lipids as bio-surfactants are innovative aspects of this WP. The application of the functional relationship between the surface free energy of the surface and the electrokinetic properties (zeta potential) of this surface is additional original aspect of the proposed research.
Methodologies: optical methods, electrophoretic mobility measurement, AFM, SEM, TEM, spectroscopy. Free energy of the layers will be determined theoretically from the wettability data.
 E.T. Castellana, P.S. Cremer, Surface Sci. Reports 61, 429–444 (2006).
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